ADDICTA: The Turkish Journal on Addictions
Research Article

The Association of Single-nucleotide Polymorphisms in Dopamine Receptor D2 Gene with Heroin Dependence in an Iranian Population


Department of Biology, University of Tabriz, 29 Bahman Bolvard Tabriz Iran


Department of Biology, Faculty of Natural Sciences, University of Tabriz, 29 Bahman Bolvard Tabriz Iran

Addicta 2018; 5: 7-12
DOI: 10.15805/addicta.2018.5.1.0016
Read: 313 Downloads: 251 Published: 15 August 2017

Drug addiction is a psychiatric condition known to be associated with the dopaminergic system, which has a vital part in the reward mechanism and etiology of drug addictions in the brain. This study’s aim is to assess the relationship of single-nucleotide polymorphisms in TaqIB and TaqIA of the DRD2 gene with the risk of drug dependence in a Northwestern Iranian population. 83 drug-dependent subjects and 83 healthy subjects have been recruited in this study. After genomic DNA isolation, two single-nucleotide polymorphisms, TaqIA (rs1800497) and TaqIB (rs1079597), were genotyped using the PCR-RFLP technique. Data analysis has been performed using the Statistical Package for the Social Sciences (SPSS-24) software for the chisquare (X2 ) test. No significant difference was detected in the TaqIA polymorphism between the control and case study groups (p > .05). In the case group, the TaqIB polymorphism was higher than the control group, showing a statistically significant variation (p < .05). The SNPs of TaqIB (rs1079597) in the DRD2 gene are associated with genetic susceptibility to drug abuse in the Iranian-Azeri population.

Citation: Fanid, L. M., Hosseinpourfeizi, M. A., Adampourzare, M., & Abdi, A. (2018). The association of single-nucleotide polymorphisms in dopamine receptor d2 gene with heroin dependence in an Iranian Population. Addicta: The Turkish Journal on Addictions, 5, 7–12.

ISSN 2148-7286 EISSN 2149-1305