ADDICTA: The Turkish Journal on Addictions
Case Report

A Diagnostic Dilemma: Nonketotic Hyperglycinemia in a Newborn with Neonatal Abstinence Syndrome—A Case Report


Iran University of Medical Sciences Faculty of Medicine, (IUMS), Tehran, Iran


Firoozabadi Clinical Research Development Unit (FACRDU), Iran University of Medical Sciences Faculty of Medicine, Tehran, Iran

Addicta 2024; 11: 16-18
DOI: 10.5152/ADDICTA.2023.23070
Read: 621 Downloads: 399 Published: 08 March 2024

Abstract: This case report highlights the difficulties in diagnosing non-ketotic hyperglycinemia in a neonate with maternal substance abuse and neonatal abstinence syndrome. Despite initial treatment for neonatal abstinence syndrome, the neonate suffered sudden cardiopulmonary arrest and had elevated glycine levels in the serum, cerebrospinal fluid, and urine, suggestive of non-ketotic hyperglycinemia. However, immediate treatment failed to improve the newborn’s condition, and the infant died of ventilator-associated pneumonia. The report underscores the importance of considering other differential diagnoses in infants with neonatal abstinence syndrome and highlights the challenges of diagnosing and treating rare genetic disorders, such as non-ketotic hyperglycinemia, in the neonatal period.

Cite this article as: Houjaghani, H., & Behmadi, R. (2024). A diagnostic dilemma: Nonketotic hyperglycinemia in a newborn with neonatal abstinence syndrome - A case report. Addicta: The Turkish Journal on Addictions, 11(1), 16-18.

ISSN 2148-7286 EISSN 2149-1305